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Related Experiment Video

Updated: Feb 24, 2026

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid

Published on: February 27, 2019

Modular salt-induced nanostructures formed by a functionalized dipeptide system.

Simona Bianco¹, Ravi R Sonani², Dipankar Ghosh¹

¹School of Chemistry, University of Glasgow, Glasgow, G12 8QQ, U.K.

|February 23, 2026

Summary

This summary is machine-generated.

Naphthalene-modified dipeptides (2NapIF) self-assemble into diverse nanostructures like fibers and nanotubes. This modular system offers potential for creating novel, meter-long, salt-responsive materials.

Keywords:

Biomaterial Cryo-EM Nanotechnology

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Related Experiment Videos

Last Updated: Feb 24, 2026

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid

Published on: February 27, 2019

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides

Published on: November 21, 2013

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Published on: February 6, 2020

Area of Science:

Nanotechnology
Supramolecular Chemistry
Materials Science

Background:

Self-assembling peptides are promising building blocks in nanotechnology.
Designing modular peptide systems is key for creating complex nanostructures.

Purpose of the Study:

To introduce and characterize a naphthalene-modified dipeptide, isoleucine-phenylalanine (2NapIF), as a modular system for self-assembly.
To explore the formation of diverse nanostructures from 2NapIF under varying conditions.

Main Methods:

Synthesis of naphthalene-modified dipeptide (2NapIF).
Induction of self-assembly using salts and mechanical stirring.
Characterization of nanostructures using cryo-electron microscopy (cryo-EM).

Main Results:

2NapIF self-assembles into fibers, nanotubes, and bundles influenced by salt concentration.
Cryo-EM revealed that hydrophobic stacking and hydrogen bonding drive nanostructure organization.
A single KCl-induced nanotube contained 18 distinct 2NapIF conformations, forming a large asymmetric unit.

Conclusions:

The 2NapIF system demonstrates remarkable modularity and conformational diversity in self-assembly.
This peptide system enables the creation of predictable, yet complex, nanostructures.
Potential applications include the development of innovative, meter-long, salt-responsive materials.