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Updated: Feb 24, 2026
Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants
Published on: June 6, 2025
Predictors of Differentiation Syndrome in Patients with Acute Promyelocytic Leukemia Following Induction Therapy: A
Wasfi Alghwyeen1, Shrouk F Mohamed2, Ahmed Shamil Hashim3
1AL- Nadeem Hospital, Ministry Of Health, Amman, Jordan.
Abstract:
Differentiation syndrome (DS) is a life-threatening condition caused by the use of differentiating agents, which are used for remission induction in acute promyelocytic leukemia (APL).This study aimed to investigate the current evidence on risk factors for DS. Related articles were searched from PubMed, Scopus, Cochrane Library, Web of Science, and China National Knowledge Infrastructure. RevMan 5.4 software was used for meta-analysis. A total of 22 studies were included in this study. Risk factors that had significant relation with DS were BMI > 25 Kg/m2 (OR: 3.87, 95% CI: 2.06 to 7.25, p < 0.0001), WBCs > 109/L (OR: 3.02, 95% CI: 1.85 to 4.92, p < 0.00001), and high risk APL (OR:2.16, 95% CI: 1.39 to 2.26, p = 0.0007). This study highlights important predictive factors for DS, with WBCs > 109/L, high-risk APL and BMI > 25 Kg/m2 as the most prominent factors.
Supplementary Information:
The online version contains supplementary material available at 10.1007/s12288-025-02036-5.
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