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Updated: Feb 25, 2026

A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
α-Arylation of Glutarimides via Ni/Ir Metallaphotoredox Cross-Electrophile Coupling
Erin L Kuker1, Dustin A Bringley1, Michael A Ischay1
1Department of Process Chemistry, Gilead Sciences Inc., Foster City, California 94404, United States.
Abstract:
Herein, we report a photochemical Ni-catalyzed cross-electrophile coupling of an α-mesylate glutarimide with aryl bromides to access 22 examples of α-arylglutarimides. Mechanistic insights allowed for the additional development of conditions that utilize a commercially available α-bromoglutarimide as a substitute for the α-mesylate glutarimide via a slow-addition protocol. These methods employ visible-light-driven metallaphotoredox catalysis to efficiently synthesize key scaffolds utilized in targeted protein degradation therapies.
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