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Updated: Feb 28, 2026

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
Molecular Testing Expansion and Utilization in Transfusion Medicine
HyoJeong Han1, Zaina Inam2, Jennifer Webb1
1Division of Hematology, Center for Cancer and Blood Disorders, Children's National Hospital; Division of Pathology & Laboratory Medicine, Children's National Hospital, 111 Michigan Avenue NW, WW-4, Suite 600, Washington, DC 20010, USA; Department of Pediatrics, George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
Abstract:
Molecular testing can identify genetic variants and accurately predict both red blood cell and platelet antigens. Furthermore, these assays can process large number of samples with quick turnaround time, allowing the techniques to be used not only in patients but also in donors. By accurately identifying recipient and donor blood antigens, appropriately matched blood products can be issued, reducing the risk of alloimmunization. These techniques can also be applied to prenatal testing of cell free fetal DNA.
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