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Related Concept Videos

Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

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Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
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Blood Transfusion01:15

Blood Transfusion

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Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
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Blood Typing01:10

Blood Typing

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Understanding an individual's blood group is a critical component of transfusion medicine. It ensures compatibility in blood transfusions, organ transplants, and even during pregnancy. Determining these blood groups involves the ABO and Rh blood typing systems, utilizing specific antigens and corresponding anti-sera to identify an individual's blood type.
Antigens are protein molecules that reside on the surface of red blood cells (RBCs). The ABO and Rh blood typing systems target...
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Bone Marrow Sampling and Transplants01:22

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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
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Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence01:22

Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence

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Generic intravenous (IV) drugs are considered bioequivalent to their branded counterparts due to their 100% bioavailability upon administration. However, variations in stability among different drug products can significantly influence their therapeutic performance, even if they are pharmaceutically equivalent.Cefuroxime, a prophylactic antimicrobial, is often used as a single-dose IV injection for patients undergoing coronary artery bypass grafting surgery. A 3 g dose typically provides...
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The ABO Blood Group01:12

The ABO Blood Group

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The ABO blood group system is a critical element of transfusion medicine, essential for determining blood compatibility in transfusions and organ transplants. It is based on specific antigens, or agglutinogens, present on the surface of red blood cells (RBCs) and corresponding antibodies, or agglutinins, in the blood plasma.
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Updated: Feb 28, 2026

Treatment of Platelet Products with Riboflavin and UV Light: Effectiveness Against High Titer Bacterial Contamination
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Patient Blood Management and Blood Product Alternatives: An Update.

Hollie M Reeves1, Kathleen K Nicol1

  • 1Transfusion Medicine Services, Department of Pathology and Laboratory Medicine, Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH 43205, USA.

Clinics in Laboratory Medicine
|February 25, 2026
PubMed
Summary

Patient blood management strategies minimize transfusions by addressing risks and optimizing blood use. Continued research into alternatives is crucial for preserving donor blood resources.

Keywords:
Blood alternativesPatient blood managementTransfusion

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Area of Science:

  • Transfusion Medicine
  • Anesthesiology
  • Surgical Care

Background:

  • Patient blood management (PBM) is critical for minimizing risks, costs, and wastage associated with blood transfusions.
  • Donor blood availability and pathogen transmission are significant concerns in healthcare.
  • Optimizing blood product utilization is essential for resource preservation.

Purpose of the Study:

  • To review current strategies in patient blood management.
  • To highlight the importance of minimizing allogeneic blood transfusions.
  • To emphasize the ongoing need for blood alternatives and resource preservation.

Main Methods:

  • Review of current literature on patient blood management techniques.
  • Analysis of strategies including restrictive transfusion protocols.
  • Examination of perioperative anemia management and hemostatic agents.

Main Results:

  • PBM strategies effectively reduce blood loss and transfusion requirements.
  • Restrictive transfusion thresholds and anemia management are key components of PBM.
  • Development of blood alternatives remains an active area of research.

Conclusions:

  • Effective patient blood management is vital for optimizing blood product use and patient safety.
  • Despite advances, reliance on donor blood necessitates continued innovation in PBM and alternatives.
  • Preserving donor blood resources requires a multifaceted approach combining current strategies and future research.