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The Cut that Counts: Surgical Site Infection Prevention Gets a Sharp Update.
Jessica Seidelman1, Deverick J Anderson1
1Division of Infectious Diseases, Department of Medicine, Duke University, Durham, NC, USA.
Infectious Disease Clinics of North America
|February 25, 2026
Summary
New guidelines emphasize targeted preoperative decolonization and antiseptic wound preparation to combat rising surgical site infections (SSIs). These essential practices aim to reduce healthcare-associated infections and improve patient outcomes.
Area of Science:
- Infection Control and Prevention
- Surgical Safety
- Epidemiology
Background:
- Surgical site infections (SSIs) are a major challenge in healthcare, characterized by persistent or increasing rates despite advancements.
- Existing infection control metrics have not adequately curbed the incidence of SSIs, necessitating updated strategies.
Purpose of the Study:
- To review and synthesize the 2022 Society for Healthcare Epidemiology of America (SHEA) updated guidelines for SSI prevention.
- To highlight newly designated essential practices and re-evaluated strategies for SSI reduction based on current evidence.
Main Methods:
- Systematic review and synthesis of the latest evidence underpinning the 2022 SHEA SSI prevention guidelines.
- Analysis of updated recommendations, including preoperative, intraoperative, and postoperative interventions.
Main Results:
- Key updates include targeted preoperative decolonization and combined antibiotic prophylaxis for specific surgeries.
- Antiseptic preparation (vaginal and wound lavage) and refined glucose control are emphasized.
- Standardized bundles and checklists are reinforced as crucial for consistent implementation.
Conclusions:
- The 2022 SHEA guidelines offer an expanded evidence base for preventing SSIs.
- Implementation of these updated essential practices is critical for healthcare facilities to combat SSIs effectively.
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