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Characterisation of the Novel HLA-B*52:131 Allele by Sequencing-Based Typing
Melchior Le Mene1, Sephora Da Silva1, Anne-Flore Le Collonnier1
1Laboratory of Immunology and Histocompatibility, Saint-Louis Hospital, APHP, Paris, France.
A new Human Leukocyte Antigen (HLA) allele, B*52:131, has been identified. This novel allele is distinguished from B*52:01:02:01 by a single nucleotide substitution within exon 3.
Area of Science:
- Immunogenetics
- Molecular biology
- Human Leukocyte Antigen (HLA) system
Background:
- The Human Leukocyte Antigen (HLA) system plays a critical role in immune response and transplantation.
- Accurate HLA typing is essential for clinical applications, including organ transplantation and disease association studies.
- The discovery of novel HLA alleles contributes to a more comprehensive understanding of immune system diversity.
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