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Adverse Events in Older Adults at Risk for Dementia During Remote Physical Exercise and Cognitive Training.
Karla J Faig1, Aidan E Steeves1, Chris A McGibbon2,3
1Horizon Health Network, Saint John, NB.
Canadian Geriatrics Journal : CGJ
|February 26, 2026
Summary
Remote physical and cognitive interventions for older adults at risk of dementia are safe. Adverse events were mostly mild, unrelated to the intervention, and managed effectively with modifications.
Area of Science:
- Gerontology
- Neurology
- Rehabilitation Medicine
Background:
- The SYNERGIC@Home study investigated remote cognitive and physical interventions for older adults at risk of dementia.
- This randomized controlled trial involved 60 community-dwelling older adults aged 60-90 years in New Brunswick, Canada.
- Participants engaged in 16 weeks of thrice-weekly remote sessions via secure videoconferencing.
Purpose of the Study:
- To determine the frequency, severity, and relationship of adverse events during remote physical and cognitive interventions.
- To assess the safety and effectiveness of managing adverse events in this population.
- To optimize participation in home-based dementia prevention programs.
Main Methods:
- Adverse events (AEs) were systematically recorded, noting type, severity, and relation to interventions.
- Intervention modifications made in response to AEs were documented.
- Data analysis focused on characterizing AEs and their management.
Main Results:
- A total of 88 AEs occurred in 70% of participants; most (71.6%) were unrelated to the intervention.
- The majority of AEs (69.3%) were mild, with musculoskeletal issues being most common (39.8%).
- One unrelated serious AE was reported; two participants discontinued due to unrelated medical issues.
Conclusions:
- Remote delivery of physical and cognitive interventions showed no serious related adverse events.
- Mild, intervention-related AEs were safely managed through physical intervention modifications.
- Home-based remote interventions are a safe and viable option for older adults at risk of dementia.
Keywords:
adverse eventscognitive trainingdementia preventionolder adultsphysical exerciserandomized controlled trialremote interventionMore Related Videos
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