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Updated: Feb 28, 2026

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model

Published on: March 20, 2020

Non-Coding RNA-Based Therapeutic Strategies in Triple-Negative Breast Cancer: A Systematic Review.

Giovana Prado Scaratti^1,2, Inaiê Maiala de Almeida Miranda^1,2, Emanuelle Nunes-Souza^1,2

¹Instituto de Pesquisa Pelé Pequeno Príncipe, Av. Silva Jardim, 1632, Curitiba 80250-060, Brazil.

International Journal of Molecular Sciences

|February 27, 2026

Summary

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Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

Cancer Therapies

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

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Biomolecules·2022

Non-coding RNAs (ncRNAs) show promise for treating triple-negative breast cancer (TNBC). Targeting specific ncRNAs in preclinical models suppressed tumor growth and metastasis, offering new therapeutic avenues.

Area of Science:

Oncology
Molecular Biology
RNA Therapeutics

Background:

Triple-negative breast cancer (TNBC) exhibits significant heterogeneity, limiting current targeted therapy success.
Most TNBC patients rely on chemotherapy, highlighting the need for novel treatment strategies.
Non-coding RNAs (ncRNAs) are emerging as potential therapeutic targets in TNBC.

Conclusions:

Preclinical evidence supports ncRNA-based therapies as promising strategies for TNBC treatment.
Targeting ncRNAs offers a novel approach to overcome therapeutic limitations in TNBC.
Further development of ncRNA-based therapies could significantly advance TNBC treatment options.

Keywords:

MicroRNA TNBC circular RNA long non-coding RNA non-coding RNA pre-clinical studies therapy

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