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Updated: Feb 28, 2026

Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials
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Emerging Biomaterials for Maxillary Sinus Augmentation: From In Vitro Insights to In Vivo Clinical Translation.

Nicole Riberti1, Michele Furlani2, Alessandra Giuliani3

  • 1Department of Clinical and Molecular Sciences, Marche Polytechnic University, 60126 Ancona, Italy.

Materials (Basel, Switzerland)
|February 27, 2026
PubMed
Summary

New biomaterials are emerging for maxillary sinus augmentation, aiming to improve upon deproteinized bovine bone mineral (DBBM). These innovations focus on enhanced vascularization and faster bone healing for dental implants.

Keywords:
biomaterialsbone regenerationdeproteinized bovine bone mineralmaxillary sinus augmentationtranslational research

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Area of Science:

  • Biomaterials Science
  • Oral and Maxillofacial Surgery
  • Regenerative Medicine

Background:

  • Maxillary sinus augmentation is crucial for dental implant success in atrophic posterior maxilla.
  • Autogenous bone, while osteogenic, has limitations like donor-site morbidity.
  • Deproteinized bovine bone mineral (DBBM) is widely used but has limited bioactivity and slow resorption.

Purpose of the Study:

  • To review emerging biomaterials for sinus floor elevation published since 2018.
  • To evaluate their potential to overcome DBBM limitations.
  • To emphasize the need for a coordinated research continuum for clinical translation.

Main Methods:

  • Systematic review of scientific literature published since 2018.
  • Critical evaluation of novel biomaterials for bone regeneration.
  • Analysis of preclinical (in vitro, animal models) and clinical study evidence.

Main Results:

  • Next-generation biomaterials aim to enhance vascularization, osteogenesis, immune modulation, and resorption control.
  • Examples include ion-releasing ceramics, growth factor-enhanced allografts, composites, hydrogels, and synthetic scaffolds.
  • These materials show promise in addressing the inert nature and slow resorption of DBBM.

Conclusions:

  • Emerging biomaterials offer enhanced properties for maxillary sinus augmentation compared to DBBM.
  • Successful clinical translation requires a comprehensive framework integrating in vitro, animal, and human studies.
  • Further research is needed to optimize these advanced materials for predictable implant-supported restorations.