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Updated: Feb 28, 2026

Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring
Published on: June 23, 2015
[When kidney disease is genetic: clues for the primary care physician]
Fadi Haidar1, David Jaques1, Philippe Khau Van Kien2
1Service néphrologie et hypertension, Département de médecine, Hôpitaux universitaires de Genève, 1211 Genève 14.
Abstract:
Genetic kidney diseases are common, accounting for up to 20-40% of severe cases in young patients. Identifying them helps avoid unnecessary immunosuppressive treatments, tailor clinical management, anticipate extra-renal complications, and provide genetic counseling. The main suggestive situations include: a treatment-resistant Focal Segmental Glomerulosclerosis (FSGS), an early-onset hematuria or a proteinuria, the structural abnormalities, the syndromic manifestations, or a family history of kidney disease. The increasing use of high-throughput sequencing (exome, gene panels, genome) improves diagnostic yield and guides follow-up, family screening, and the assessment of eligibility for living kidney donation among potential donors within a given family.
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