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[Fatigue in dialysis : a major symptom, multiple determinants].
Paulo De Sousa Mendes1, David Jaques2, Patrick Saudan2
1Service de médecine interne, Hôpital de La Tour, 1217 Meyrin/Genève.
Revue Medicale Suisse
|February 27, 2026
Summary
Fatigue significantly impacts hemodialysis patients, affecting quality of life. Dialysis recovery time (DRT) measures post-dialysis fatigue, with intradialytic exercise and education offering potential non-pharmacological treatments.
Area of Science:
- Nephrology
- Patient-centered outcomes
- Quality of life research
Background:
- Fatigue is a prevalent and debilitating symptom in hemodialysis patients, impacting up to 90% of individuals.
- This fatigue stems from physiological stress during dialysis and individual factors like metabolic and psychosocial determinants.
- Acute post-dialysis fatigue significantly impairs patients' overall quality of life.
Purpose of the Study:
- To review current evidence on fatigue and Dialysis Recovery Time (DRT) in hemodialysis patients.
- To discuss therapeutic strategies for managing post-dialysis fatigue.
- To highlight non-pharmacological interventions such as intradialytic exercise and psycho-educational programs.
Main Methods:
- Literature review of studies on fatigue and DRT in hemodialysis.
- Analysis of patient-centered outcomes related to fatigue.
- Synthesis of evidence on therapeutic interventions, focusing on non-pharmacological approaches.
Main Results:
- Dialysis Recovery Time (DRT) is identified as a patient-centered metric for assessing acute post-dialysis fatigue.
- Non-pharmacological interventions, including intradialytic exercise and psycho-educational strategies, show promise in managing fatigue.
- Evidence supports the role of these interventions in improving patient well-being and quality of life.
Conclusions:
- Fatigue is a major challenge for hemodialysis patients, directly affecting their quality of life.
- DRT offers a valuable tool for quantifying and understanding post-dialysis fatigue.
- Intradialytic exercise and psycho-educational interventions represent key non-pharmacological strategies for alleviating fatigue in this population.
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