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Growth of Cartilage and Bone Tissue

Growth of Cartilage and Bone Tissue

Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...

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Updated: May 4, 2026

Matrix-assisted Autologous Chondrocyte Transplantation for Remodeling and Repair of Chondral Defects in a Rabbit Model

Matrix-assisted Autologous Chondrocyte Transplantation for Remodeling and Repair of Chondral Defects in a Rabbit Model

Published on: May 21, 2013

Chondromyxoid Fibroma: An Updated Review.

Jun Nishio¹, Yuki Shinohara², Yoshiro Chijiiwa²

¹Section of Orthopaedic Surgery, Department of Medicine, Fukuoka Dental College, Fukuoka, Japan; nishio@fdcnet.ac.jp.

In Vivo (Athens, Greece)

|February 27, 2026

Summary

This summary is machine-generated.

Chondromyxoid fibroma (CMF) is a rare bone tumor. This review details its clinical, imaging, and molecular features, highlighting GRM1 alterations as a diagnostic marker.

Keywords:

COL12A1 Chondromyxoid fibroma GRM1 chondroblastoma chondrosarcoma osteosarcoma phosphaturic mesenchymal tumor review

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Clinical Protocol of Producing Adipose Tissue-Derived Stromal Vascular Fraction for Potential Cartilage Regeneration

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Last Updated: May 4, 2026

Matrix-assisted Autologous Chondrocyte Transplantation for Remodeling and Repair of Chondral Defects in a Rabbit Model

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$Autologous Microfractured and Purified Adipose Tissue for Arthroscopic Management of Osteochondral Lesions of the Talus$

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Clinical Protocol of Producing Adipose Tissue-Derived Stromal Vascular Fraction for Potential Cartilage Regeneration

Clinical Protocol of Producing Adipose Tissue-Derived Stromal Vascular Fraction for Potential Cartilage Regeneration

Published on: September 29, 2018

Area of Science:

Orthopedic Oncology
Skeletal Radiology
Molecular Pathology

Background:

Chondromyxoid fibroma (CMF) is a rare, benign cartilaginous neoplasm.
Typically affects long bone metaphyses in young individuals.
Clinical presentation often involves pain and swelling.

Purpose of the Study:

To provide an updated overview of CMF.
Discuss clinical, radiological, histological, immunohistochemical, and molecular features.
Explore differential diagnoses for CMF.

Main Methods:

Review of clinical, imaging, histological, and molecular data.
Analysis of radiographic and MRI characteristics.
Evaluation of immunohistochemical and genetic findings.

Main Results:

Radiographs show well-defined eccentric lytic lesions.
MRI reveals characteristic signal intensities and enhancement patterns.
Histology demonstrates lobules of cells in a myxoid background with zonal architecture.
GRM1 gene alterations and GRM1 positivity are key molecular findings.

Conclusions:

CMF diagnosis relies on integrated clinical, imaging, and histological assessment.
GRM1 positivity serves as a reliable marker for CMF.
Treatment involves curettage or resection, with a risk of recurrence.