Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chemical Synapses01:26

Chemical Synapses

12.1K
Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
12.1K
Chemical Synapses01:26

Chemical Synapses

5.2K
Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
5.2K
Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

2.1K
The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
2.1K
Classification of Skeletal Muscle Relaxants01:28

Classification of Skeletal Muscle Relaxants

3.2K
Skeletal muscle relaxants are a group of drugs that can reduce muscle stiffness and induce temporary paralysis to relieve pain. These agents can act centrally to reduce muscle tone or spasms in painful conditions such as multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), or spinal injuries; they are called antispasmodics or spasmolytics.
Peripherally acting skeletal muscle relaxants interfere with the neurotransmission at the neuromuscular end plate to induce paralysis during...
3.2K
Depolarizing Blockers: Mechanism of Action01:28

Depolarizing Blockers: Mechanism of Action

3.2K
Depolarizing blockers act on skeletal muscle fibers' membranes and induce their depolarization. Most depolarizing blockers have two quaternary N+ atoms that bind the nicotinic acetylcholine receptors and cause neuromuscular blockade within minutes.
Succinylcholine is the most commonly used depolarizing blocker. Chemically, it constitutes two molecules of acetylcholine joined together by an acetate methyl group. They act on the receptors in the same way as acetylcholine. Because...
3.2K
Myasthenia Gravis: Diagnostic Tests01:15

Myasthenia Gravis: Diagnostic Tests

2.9K
Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
2.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Role of Microbiome-Associated Metabolites and Their Clinical Implications in Traumatic Brain Injury: A Scoping Review.

Neurocritical care·2026
Same author

AHT diagnoses: The influences of clinical presentation and evidence of impact.

Child abuse & neglect·2026
Same author

Plants Anticipating Help: A New Hypothesis in Plant Defence Theory.

Ecology letters·2025
Same author

Opportunity Knocks? Toward Improving Outcome in Children With Acquired Brain Injury.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·2025
Same author

Identifying Predictors of Extended Intensive Care Unit Stay Following Posterior Spinal Fusion for Adolescent Idiopathic Scoliosis: An Analysis of 101 ACS NSQIP Pediatric Participating Centers.

The Iowa orthopaedic journal·2025
Same author

Effects of Neonatal Hypoxic-Ischemic Injury on Brain Sterol Synthesis and Metabolism.

Neuropediatrics·2023
Same journal

Hemangiomas: Beyond the Skin.

Pediatrics in review·2026
Same journal

More Than Innocent: A Continuous Murmur in an Infant.

Pediatrics in review·2026
Same journal

Genetic Testing.

Pediatrics in review·2026
Same journal

Visual Diagnosis: Term Infant With a Hemorrhagic Dermatologic Lesion.

Pediatrics in review·2026
Same journal

Long-Term Complications of Sickle Cell Disease.

Pediatrics in review·2026
Same journal

Pediatric Multisystemic Illness With Cardiac Involvement: A Diagnostic Challenge.

Pediatrics in review·2026
See all related articles

Related Experiment Video

Updated: Mar 2, 2026

Single-stage Dynamic Reanimation of the Smile in Irreversible Facial Paralysis by Free Functional Muscle Transfer
19:53

Single-stage Dynamic Reanimation of the Smile in Irreversible Facial Paralysis by Free Functional Muscle Transfer

Published on: March 1, 2015

106.6K

Acute Flaccid Paralysis.

Amanda M Dave1,2, Kyoko Fukahori1,3, Meghan Mack1,3

  • 1University of Pittsburgh Medical Center, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania.

Pediatrics in Review
|February 28, 2026
PubMed
Summary
This summary is machine-generated.

Acute flaccid paralysis involves sudden weakness from various causes like infections or autoimmune conditions. Effective management requires a comprehensive, multidisciplinary approach to treatment and rehabilitation.

More Related Videos

Utility of Dissociated Intrinsic Hand Muscle Atrophy in the Diagnosis of Amyotrophic Lateral Sclerosis
08:16

Utility of Dissociated Intrinsic Hand Muscle Atrophy in the Diagnosis of Amyotrophic Lateral Sclerosis

Published on: March 4, 2014

33.4K
Assessing Forelimb Function after Unilateral Cervical SCI using Novel Tasks: Limb Step-alternation, Postural Instability and Pasta Handling
08:11

Assessing Forelimb Function after Unilateral Cervical SCI using Novel Tasks: Limb Step-alternation, Postural Instability and Pasta Handling

Published on: September 16, 2013

22.6K

Related Experiment Videos

Last Updated: Mar 2, 2026

Single-stage Dynamic Reanimation of the Smile in Irreversible Facial Paralysis by Free Functional Muscle Transfer
19:53

Single-stage Dynamic Reanimation of the Smile in Irreversible Facial Paralysis by Free Functional Muscle Transfer

Published on: March 1, 2015

106.6K
Utility of Dissociated Intrinsic Hand Muscle Atrophy in the Diagnosis of Amyotrophic Lateral Sclerosis
08:16

Utility of Dissociated Intrinsic Hand Muscle Atrophy in the Diagnosis of Amyotrophic Lateral Sclerosis

Published on: March 4, 2014

33.4K
Assessing Forelimb Function after Unilateral Cervical SCI using Novel Tasks: Limb Step-alternation, Postural Instability and Pasta Handling
08:11

Assessing Forelimb Function after Unilateral Cervical SCI using Novel Tasks: Limb Step-alternation, Postural Instability and Pasta Handling

Published on: September 16, 2013

22.6K

Area of Science:

  • Neurology
  • Immunology
  • Infectious Diseases

Background:

  • Acute flaccid paralysis (AFP) is a critical clinical syndrome characterized by the sudden onset of muscle weakness.
  • AFP can stem from diverse etiologies, encompassing autoimmune disorders, viral infections, and primary neurological conditions.
  • Prompt diagnosis and intervention are crucial for managing AFP and preventing long-term sequelae.

Purpose of the Study:

  • To review the multifaceted causes of acute flaccid paralysis.
  • To outline current management strategies for AFP.
  • To emphasize the importance of a multidisciplinary approach in AFP care.

Main Methods:

  • Literature review of studies on acute flaccid paralysis.
  • Analysis of etiological factors contributing to AFP.
  • Synthesis of treatment and rehabilitation protocols.

Main Results:

  • Acute flaccid paralysis presents with rapid muscle weakness.
  • Identified causes include autoimmune diseases, viral infections, and neurological disorders.
  • Supportive care forms the cornerstone of management.

Conclusions:

  • Management of acute flaccid paralysis is primarily supportive.
  • A multidisciplinary team approach is essential for optimizing treatment and rehabilitation outcomes.
  • Early and coordinated care improves patient prognosis in AFP.