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Cytokine specificity in macrophages: JAK-STAT and beyond

Josje M A Huisman1, Alexandra Drakaki1, Thomas Decker2

  • 1Department of Medical Biochemistry, location AMC, Amsterdam, The Netherlands; Amsterdam institute for Immunology and Infectious diseases, Amsterdam UMC, location AMC, Amsterdam, The Netherlands; Amsterdam Cardiovascular Sciences Institute, Amsterdam UMC, location AMC, Amsterdam, The Netherlands.

Trends in Immunology
|February 28, 2026
PubMed
Summary

Macrophages use JAK-STAT signaling to adapt to cytokine signals and maintain tissue balance. Understanding this process is crucial for controlling inflammation and resolving diseases.

Keywords:
JAK-STATcytokine-specificity paradoxenhancersmacrophagestranscription factors

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