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Related Experiment Video

Updated: Jun 16, 2026

Technique of Subnormothermic Ex Vivo Liver Perfusion for the Storage, Assessment, and Repair of Marginal Liver Grafts

Technique of Subnormothermic Ex Vivo Liver Perfusion for the Storage, Assessment, and Repair of Marginal Liver Grafts

Published on: August 13, 2014

Machine Perfusion in Liver Transplant from Marginal Donors: Current Practices and Future Directions.

Huiying Zhou^1,2, Cheng Wang^1,2, Jiaxin Zhao^1,2

¹Department of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Fourth Affiliated Hospital, School of Medicine, Zhejiang University, No. N1, Shangcheng Avenue, Yiwu, Zhejiang, 322000, China.

Journal of Clinical and Experimental Hepatology

|March 2, 2026

Summary

Machine perfusion enhances high-risk donor livers for transplantation, improving outcomes and expanding the organ pool. This dynamic preservation technique overcomes static cold storage limitations, reducing injury and enabling viability assessment.

Keywords:

HOPE NMP machine perfusion marginal livers viability of marginal livers

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Last Updated: Jun 16, 2026

Technique of Subnormothermic Ex Vivo Liver Perfusion for the Storage, Assessment, and Repair of Marginal Liver Grafts

Technique of Subnormothermic Ex Vivo Liver Perfusion for the Storage, Assessment, and Repair of Marginal Liver Grafts

Published on: August 13, 2014

Functional Human Liver Preservation and Recovery by Means of Subnormothermic Machine Perfusion

Functional Human Liver Preservation and Recovery by Means of Subnormothermic Machine Perfusion

Published on: April 27, 2015

A Small Animal Model of Ex Vivo Normothermic Liver Perfusion

A Small Animal Model of Ex Vivo Normothermic Liver Perfusion

Published on: June 27, 2018

Area of Science:

Hepatology
Transplantation Medicine
Organ Preservation Technology

Background:

Rising chronic liver disease incidence and organ shortage necessitate expanded criteria donor (ECD) utilization.
High-risk donor livers are increasingly used, posing challenges for traditional preservation methods.
Static cold preservation has limitations in assessing and improving marginal graft quality.

Purpose of the Study:

To review the clinical applications and classifications of machine perfusion devices for liver transplantation.
To explore future strategies for assessing marginal liver viability and optimizing organ function.
To highlight the role of machine perfusion in mitigating post-transplant complications.

Main Methods:

Review of current literature on ex situ machine perfusion in liver transplantation.
Classification of existing machine perfusion devices and their technologies.
Discussion of emerging techniques for graft assessment and intervention.

Main Results:

Ex situ machine perfusion mitigates ischemia-reperfusion injury compared to static cold preservation.
Machine perfusion allows continuous assessment of organ quality and viability testing.
This technology optimizes the use of marginal grafts, expanding the donor liver pool.

Conclusions:

Machine perfusion represents a significant advancement over static cold preservation for liver transplantation.
Dynamic preservation enhances graft quality, reduces complications, and enables better utilization of ECD livers.
Future strategies focus on advanced viability assessment and therapeutic interventions during perfusion.