Machine-learning-derived phenotypes of hypertensive patients using multidimensional clinical and echocardiographic...

We applied unsupervised machine learning clustering to a large cohort of hypertensive patients undergoing echocardiography with strain imaging to identify phenotypes with distinct clinical profiles, comorbidities, remodelling trajectories, and outcomes.

We analysed 1607 patients from the STRATS-HHD registry who underwent echocardiography at baseline and after 6-18 months of therapy. Twenty clinical, laboratory, and echocardiographic variables-including left atrial and left ventricular strain-underwent principal component analysis and K-means clustering (K = 4). Clusters were derived in the SNUBH cohort (n = 1204) and validated in the CAUH cohort (n = 403), two institutional subsets of the registry. Remodelling trajectories were assessed using baseline-adjusted models, and associations with outcomes were evaluated using multivariable Cox regression. Four clusters emerged: (i) atrial fibrillation-predominant, with advanced remodelling and the highest event risk; (ii) elderly, with metabolic-renal comorbidities but preserved function; (iii) middle-aged, with prevalent coronary disease and relatively preserved function; and (iv) younger, with severe hypertension, marked strain impairment, and the greatest remodelling regression with therapy. Prognosis varied: cluster 1 had the highest risk of cardiovascular death, heart failure hospitalization, stroke, and major adverse cardiovascular events (MACE); cluster 2 exhibited increased cardiovascular death and intermediate heart failure hospitalization risk; cluster 3 showed elevated coronary risk; and cluster 4 the most favourable outcomes. Associations between medication and remodelling varied, with renin-angiotensin blockade linked to LV mass regression in cluster 4.

Machine learning -based clustering incorporating strain identified four distinct HHD phenotypes with divergent remodelling, therapeutic responses, and outcomes. Data-driven phenotyping may improve risk stratification and enable tailored management in hypertension.