Hyperdiluted triamcinolone injection therapy for infraorbital herniated fat pads
Tamara Semenovych1, Isabella Rosellini2, Jessie Lim Jia Min3
1Artzplan Beauty Clinic, Vienna, Austria.
JPRAS Open
|March 2, 2026
Summary
Hyperdiluted triamcinolone acetonide (TAC) injections effectively reduced infraorbital fat pads in a small case series. This minimally invasive approach offers a potential non-surgical option for aesthetic concerns, though caution is advised due to potential side effects.
Area of Science:
- Aesthetic dermatology
- Minimally invasive cosmetic procedures
Background:
- Infraorbital herniated fat pads are a common aesthetic concern.
- Surgical correction is typical, but minimally invasive options are limited.
- Intralesional triamcinolone acetonide (TAC) can cause localized atrophy.
Purpose of the Study:
- To evaluate outcomes of treating infraorbital fat pads with hyperdiluted TAC (1:20).
- To explore steroid-related mechanisms affecting adipose tissue in this context.
Main Methods:
- Retrospective case series of nine patients with infraorbital fat pad protrusion.
- TAC hyperdiluted 1:20 with normal saline injected into fat pads.
- 1-3 sessions at 4-week intervals; photographic and clinical assessments.
Main Results:
- All nine patients showed visible reduction in infraorbital bulging.
- Improvement was noted over several weeks, with 1-2 sessions for mild/moderate cases.
- No serious complications; transient side effects like edema and erythema resolved.
Conclusions:
- Hyperdiluted TAC (1:20) may offer a conservative, minimally invasive method for infraorbital fat reduction.
- The mechanism may involve steroid-induced adipose atrophy.
- This approach is investigational and requires cautious application due to risks of atrophy and dyspigmentation.
Keywords:
Adipocyte apoptosisAesthetic medicineEyebagsFat apoptosisInfraorbital herniationNon-surgical rejuvenationMore Related Videos
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