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Responding appropriately to safety signals in infants exposed to the 6-month BDLLfx/BDLCfz regimen in utero

Marian Loveday1,2, Emma Clarence1, James C M Brust3

  • 1HIV and other Infectious Diseases Research Unit (HIDRU), South African Medical Research Council, Durban, South Africa.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|March 3, 2026
PubMed
Abstract

No abstract available in PubMed .

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Development of Immunocompetence01:22

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...

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