Photoinduced Dearomative Oxyimination of Indoles Using Oxime Esters as Bifunctional Radical Precursors
Ming Yang1, You Zi2, Shun-Jun Ji1
1Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science & Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou 215123, P. R. China.
Abstract:
A photoinduced, metal-free, and regioselective oxyimination of indole derivatives has been developed, enabling efficient difunctionalization via simultaneous C-O and C-N bond formation. Using oxime esters as dual radical precursors, this mild and sustainable strategy achieves a high atom economy and excellent diastereoselectivity. It can be applied to benzofuran and benzothiophene derivatives. This method provides a versatile and practical approach for dearomative transformations, offering new opportunities for the diastereoselective functionalization of indole derivatives.
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