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Related Concept Videos

Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

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Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
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Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
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Live bacteria microneedles for biomedical applications.

Junfeng Feng1, Yu Wang1, Letong Huang1

  • 1Special Key Laboratory of Oral Disease Research and High Education Institute in Guizhou Province, School and Hospital of Stomatology, Zunyi Medical University, Zunyi 563000, China.

Journal of Materials Chemistry. B
|March 5, 2026
PubMed
Summary
This summary is machine-generated.

Microneedles (MNs) offer a promising minimally invasive method for delivering live bacteria as therapeutic agents. This approach enhances bacterial therapy for wound healing, cancer, vaccination, and fungal infections, overcoming delivery challenges.

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Area of Science:

  • Biomedical Engineering
  • Microbiology
  • Therapeutics

Background:

  • Bacteria exhibit dual roles as pathogens and therapeutic agents, with potential in oncology, intestinal therapy, and wound healing.
  • Challenges in bacterial therapy include biosafety, delivery methods, and colonization rates, limiting clinical applications.
  • Microneedles (MNs) are versatile, minimally invasive devices with potential to improve bacterial therapy delivery.

Purpose of the Study:

  • To review recent advancements in microneedle-mediated live bacterial delivery systems.
  • To highlight applications of this technology in wound healing, cancer therapy, vaccination, and fungal infection treatment.
  • To discuss representative bacteria used and their mechanisms, alongside challenges and future prospects.

Main Methods:

  • Literature review of microneedle-mediated bacterial delivery systems.
  • Analysis of bacterial properties relevant to therapeutic applications.
  • Exploration of challenges and future directions in the field.

Main Results:

  • Microneedles show significant potential for enhancing bacterial therapy delivery.
  • Applications span wound healing, cancer treatment, vaccination, and antifungal therapies.
  • Key bacteria and their mechanisms in MN-mediated systems are discussed.

Conclusions:

  • Microneedle technology offers a promising solution to overcome limitations in bacterial therapy delivery.
  • Further research is needed to address challenges and fully realize the potential of MN-mediated bacterial therapy.
  • This approach holds promise for advancing diverse biomedical and clinical applications.