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Examining Local Network Processing using Multi-contact Laminar Electrode Recording

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Single-Sided Multimodal Neural Probe Enabling Co-Localized Recording of Electrical and Chemical Signals.

Giheon Kim¹, Seungjun Lee^1,2, Jonghee Eun²

¹School of Electronic and Electrical Engineering College of IT Engineering, Kyungpook National University, Daegu 41566, Republic of Korea.

ACS Chemical Neuroscience

|March 5, 2026

Summary

This summary is machine-generated.

Researchers developed a novel multimodal neural probe for simultaneous brain electrical and chemical signal monitoring. This advancement allows for precise real-time tracking of neurochemical dynamics and neural activity, aiding neurological disorder research.

Keywords:

electrophysiology laser-induced graphene multimodal neural probe neurochemical sensing single-sided integration

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Area of Science:

Neuroscience
Biomedical Engineering
Materials Science

Background:

Understanding brain function requires correlating neural activity with neurochemical signaling.
Existing multimodal probes face spatial and temporal mismatches between recording and sensing sites due to fabrication limitations.

Purpose of the Study:

To develop a single-sided multimodal neural probe with integrated chemical-sensing and neural-recording electrodes in close proximity.
To overcome fabrication constraints and improve spatial resolution for simultaneous brain signal monitoring.

Main Methods:

Utilized a sequential laser-induced graphene process on a flexible polyimide substrate.
Functionalized electrodes with glucose oxidase for chemical sensing and black platinum for electrical recording.
Fabricated distinct electrodes without photolithography or multilayer alignment.

Main Results:

Achieved reliable in vitro glucose detection with stable, concentration-dependent, and selective responses.
Demonstrated low impedance and high signal fidelity for extracellular spike recording with black platinum electrodes.
Validated the probe in vivo for real-time glucose dynamics tracking and simultaneous neural spike acquisition in the mouse hippocampus.

Conclusions:

The novel fabrication strategy enhances spatial resolution in multimodal neural interfacing.
Minimizing diffusion delays enables precise temporal correlation between electrical and chemical brain signals.
This probe is a valuable tool for investigating dynamic neurochemical and electrophysiological processes in the brain.