Synthesis of LiYbF₄: Tm-Based Core-Shell Upconversion Nanoparticles for Biofilm Eradication on Titanium Implants via...

Area of Science:

• Biomaterials Science
• Nanotechnology
• Medical Devices

Background:

• Bacterial biofilms on implants cause inflammation and failure.
• Conventional treatments like mechanical removal and antibiotics have limitations.

Purpose of the Study:

• To develop near-infrared (NIR)-active antibacterial titanium (Ti) implant surfaces.
• To utilize upconversion nanoparticles (UCNPs) for enhanced antibacterial efficacy.
• To create infection-resistant implants with improved biocompatibility.

Main Methods:

• Synthesized LiYbF4 core-shell UCNPs (∼10 nm core, ∼2 nm shell).
• Coated UCNPs onto sandblasted and acid-etched Ti implants using polydopamine (PDA) and ultrasonic spraying.
• Activated UCNPs with NIR light (980 nm) to generate UV light for photoelectron therapy.

Main Results:

• Achieved high biofilm eradication rates: 98.9% in vitro and 99.99% in vivo.
• Demonstrated good biocompatibility of the modified Ti implant surfaces.
• PDA coating enhanced light absorption and energy transfer.

Conclusions:

• NIR-active UCNP-coated Ti implants show significant antibacterial efficacy against biofilms.
• This photoelectron therapy approach offers a promising strategy for infection-resistant medical implants.
• The localized UV generation minimizes off-target effects, enhancing clinical translatability.