Activity determination of ⁶⁸Ga by an extended TDCR-Čerenkov method

Area of Science:

• Nuclear Physics
• Radiochemistry
• Medical Imaging

Background:

• ⁶⁸Ga is a key radionuclide for Positron Emission Tomography (PET) imaging.
• Its decay properties, including high-energy positron emission, are suitable for Čerenkov radiation detection.
• Čerenkov radiation offers a method to measure activity in aqueous solutions, excluding electron capture contributions.

Purpose of the Study:

• To extend the TDCR-Čerenkov analytical model for ⁶⁸Ga efficiency computation.
• To validate the extended model by comparing its results with a well-established method.
• To ensure accurate activity measurements for ⁶⁸Ga in PET applications.

Main Methods:

• Utilized the decay scheme of ⁶⁸Ga to adapt the TDCR-Čerenkov model.
• Performed efficiency computations using the extended TDCR-Čerenkov analytical model.
• Compared results with the 4πβ(Č)-γ coincidence counting method.

Main Results:

• The extended TDCR-Čerenkov model successfully computed ⁶⁸Ga efficiency.
• A small discrepancy of 0.21% was observed when comparing with the 4πβ(Č)-γ method.
• The results demonstrate excellent agreement within the uncertainty margins.

Conclusions:

• The refined TDCR-Čerenkov model provides accurate activity measurements for ⁶⁸Ga.
• This method is a reliable alternative for quantifying ⁶⁸Ga in PET studies.
• The findings support the use of this model in nuclear metrology and medical imaging.