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Development of Pyoderma Gangrenosum in a Patient with Acquired Reactive Perforating Collagenosis.
Yuki Mizutani1, Kyoko Sugioka1, Tomoko Akeda1
1Department of Dermatology, Graduate School of Medicine, Mie University, Tsu, Japan.
Pyoderma gangrenosum (PG) can occur secondary to acquired reactive perforating collagenosis (ARPC). Adalimumab effectively treated this rare association in a patient with diabetes, offering a safe alternative to corticosteroids.
Area of Science:
- Dermatology
- Immunology
Background:
- Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis with unclear pathogenesis.
- Acquired reactive perforating collagenosis (ARPC) involves transepidermal collagen elimination, often linked to diabetes or renal dysfunction.
- ARPC is not typically recognized as a precursor to PG.
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