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Effects of Exogenous Adenosine on Heart Rate Variability Indices in Newborn Rats.

S V Kuznetsov1, N N Kuznetsova2

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Bulletin of Experimental Biology and Medicine
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Adenosine affects heart rate variability differently in newborn rats compared to adults, with prolonged effects in neonates. This highlights developmental changes in cardiovascular regulation mechanisms during early life.

Keywords:
adenosineheart rate variabilitynewborn ratsrespiration

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Area of Science:

  • Cardiovascular Physiology
  • Developmental Biology
  • Pharmacology

Background:

  • Adenosine plays a crucial role in cardiovascular regulation.
  • Understanding the developmental impact of adenosine on heart rate dynamics is essential.

Purpose of the Study:

  • To investigate the effects of adenosine on heart rate variability (HRV), heart rate (HR), and respiratory rate (RR) in rats at different developmental stages (P3, P16, P30).
  • To characterize the age-dependent changes in autonomic nervous system influences on heart rhythm following adenosine receptor activation.

Main Methods:

  • Intraperitoneal administration of adenosine (90 mg/kg) to rats at postnatal days 3, 16, and 30.
  • Analysis of heart rate variability (HRV), heart rate (HR), and respiratory rate (RR) under baseline and post-adenosine conditions.
  • Assessment of parasympathetic, sympathetic, and neurohumoral regulatory mechanisms.

Main Results:

  • Newborn rats (P3) exhibited a prolonged negative chronotropic effect of adenosine, contrasting with the transient effect in adult animals.
  • Adenosine receptor activation led to age-specific alterations in heart rhythm regulation mechanisms.
  • A significant decrease in parasympathetic influences was observed during the first two weeks (P3-P16), followed by a significant increase by P30.
  • Adenosine administration showed no significant impact on sympathetic or neurohumoral factors during the first month of life.

Conclusions:

  • Adenosine exerts age-dependent effects on cardiac autonomic regulation in developing rats.
  • The study reveals distinct developmental trajectories of parasympathetic and sympathetic modulation of heart rhythm in response to adenosine.
  • These findings underscore the critical role of adenosine signaling in the maturation of cardiovascular control systems.