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Updated: Mar 12, 2026

Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport
Published on: November 27, 2016
Ileal bile acid transporter inhibitors for chronic constipation in the elderly
Payila Satya Raghava Aneesh1, Venkatesh Vaithiyam2, Ravi Teja Reddy1
1Department of Gastroenterology, Govind Ballabh Pant Institute of Post Graduate Medical Education and Research, New Delhi 110002, Delhi, India.
Abstract:
We read with great interest and commended Sakai et al for their valuable study on the efficacy of elobixibat in elderly patients with chronic constipation (CC). This study provides valuable insights into the safety and efficacy of elobixibat in elderly patients with CC. We have a few critical points regarding the study methodology and evaluation of CC in the elderly population. The authors have not commented on the exclusion of possible drug-related constipation, as most of their elderly patients have comorbid illness, structural causes of constipation, evaluation of gastrointestinal motility, and advocating for a more comprehensive workup for CC in the elderly. This article also provides a comprehensive review of the workup of CC in the elderly, as well as a review of the available evidence on ileal bile acid transporter inhibitor - elobixibat in CC.
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