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Machine learning-assisted sensor array based on CeO2 nanozymes for intelligent recognition of multiple synthetic
Fang Zhu1, Yunxiang Fan1, Jiaqi Zang1
1School of the Environment and Safety Engineering, School of the Emergency Management, Jiangsu University, Key Laboratory of Zhenjiang, Jiangsu University, Zhenjiang, 212013, China.
Analytica Chimica Acta
|March 11, 2026
Summary
A new nanozyme sensor array precisely identifies five synthetic phenolic antioxidants. This method aids in monitoring and preventing the harmful overuse of these common food and plastic additives.
Area of Science:
- Analytical Chemistry
- Materials Science
- Nanotechnology
Background:
- Synthetic phenolic antioxidants are widely used in food, rubber, and plastics.
- Excessive intake of these compounds poses potential human health risks.
Purpose of the Study:
- To develop a novel nanozyme sensor array for discriminating between five specific synthetic phenolic antioxidants.
- To establish a reliable method for identifying and quantifying these antioxidants in real-world samples.
Main Methods:
- Synthesis of three Cerium Oxide (CeO2) nanozymes with distinct morphologies and peroxidase-like activity.
- Construction of a CeO2 nanozyme sensor array for pattern recognition-based discrimination.
- Integration with machine learning for a dual-stage prediction model (classification and quantification).
Main Results:
- The CeO2 nanozymes exhibited varying inhibition responses to different synthetic phenolic antioxidants based on their chemical structures.
- The sensor array successfully discriminated among five antioxidants: propyl gallate (PG), butylated hydroxyanisole (BHA), tertiary butylhydroquinone (TBHQ), butylated hydroxytoluene (BHT), and 3,5-Di-tert-butyl-4-hydroxybenzoic acid (BHT-COOH).
- A machine learning model enabled accurate identification and concentration determination in actual samples, demonstrating practical applicability.
Conclusions:
- The developed CeO2 nanozyme sensor array offers a novel and effective method for identifying synthetic phenolic oxidants.
- This technology can improve oversight regarding the overuse of synthetic antioxidants, contributing to better public health and safety.
