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Updated: Mar 13, 2026

Constructing Cyclic Peptides Using an On-Tether Sulfonium Center
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Metabolite Mediated Protein Macrocyclization.

Zachary E Paikin1, Ana Villalobos Galindo1, Monika Raj1

  • 1Department of Chemistry, Emory University, Atlanta, Georgia 30322, United States.

Synlett : Accounts and Rapid Communications in Synthetic Organic Chemistry
|March 12, 2026
PubMed
Summary

This study introduces 4-hydroxynonenal (4-HNE) for protein macrocyclization, enhancing protein stability. This novel method improves proteolytic and thermal stability for engineered proteins.

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