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Related Concept Videos

Gallbladder01:17

Gallbladder

2.8K
The gallbladder is a small, pear-shaped organ that plays a crucial role in our digestive system. Measuring about 10 cm in length, it is comparable in size to a kiwi fruit and is located in a hollow area on the lower surface of the liver. The gallbladder's primary function is to store and concentrate bile, a fluid produced by the liver that aids in digestion.
The gallbladder's anatomy consists of three regions: the fundus, body, and neck. Extending from the neck, the cystic duct joins...
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Diseases of the Liver and Gallbladder01:26

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Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
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Endoscopic Procedures V: ERCP01:26

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Endoscopic Retrograde Cholangiopancreatography (ERCP) is a diagnostic procedure that combines endoscopy and fluoroscopy to diagnose and treat conditions related to the bile ducts, pancreatic ducts, and gallbladder. This procedure is beneficial for identifying and addressing blockages, gallstones, strictures, and tumors within the biliary or pancreatic systems. ERCP is both diagnostic and therapeutic, offering the ability to visualize and treat identified problems in one session.
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Updated: May 5, 2026

Laparoscopic Common Bile Duct Exploration in Patients with a Previous History of Biliary Tract Surgery
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Porcelain gallbladder revisited.

Reza Zahedpasha1,2, Mary Salvatore3

  • 1Jacobi Medical Center/North Central Bronx Hospital, New York, NY, USA. zahedpasha.r@gmail.com.

Journal of Ultrasound
|March 13, 2026
PubMed
Summary
This summary is machine-generated.

Porcelain gallbladder (PG) involves gallbladder wall calcification, strongly linked to gallstones and gallbladder cancer. Understanding its inflammation and molecular pathways is key for early detection and management.

Keywords:
CholelithiasisChronic inflammationGallbladder carcinomaPorcelain gallbladderUltrasound

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Area of Science:

  • Gastroenterology
  • Pathology
  • Oncology

Background:

  • Porcelain gallbladder (PG) is a rare condition characterized by gallbladder wall calcification.
  • It has significant clinical importance due to its association with gallbladder cancer (5-22%).

Purpose of the Study:

  • To review the epidemiology, pathophysiology, and molecular mechanisms of porcelain gallbladder development.
  • To explore the relationship between calcification patterns and malignancy.
  • To identify potential associations with urinary bladder calcification and malignancy.

Main Methods:

  • Literature review synthesizing current knowledge on porcelain gallbladder.
  • Analysis of epidemiological data, risk factors, and molecular pathways.
  • Examination of emerging evidence, including bacterial roles and calcification patterns.

Main Results:

  • Cholelithiasis (gallstones) is the primary risk factor (>60%), with female sex, age, and metabolic disorders also contributing.
  • Pathogenesis involves sustained inflammation, fibrosis, scarring, and calcium deposition.
  • Estrogen influences female predominance; *Helicobacter pylori* may play a role.

Conclusions:

  • Porcelain gallbladder pathogenesis is multifactorial, involving inflammation and molecular changes.
  • The link between calcification patterns and cancer risk requires further investigation.
  • Investigating urinary bladder calcification alongside porcelain gallbladder may reveal future research avenues.