Noninvasive imaging in peripheral arterial disease: Techniques, protocols, and clinical applications
Yolanda Bryce1, Jill Sommerset2, Constantino Peña3
1Radiology Department, Memorial Sloan Kettering Cancer Center, New York, NY.
Techniques in Vascular and Interventional Radiology
|March 13, 2026
Summary
Noninvasive imaging is key for diagnosing and managing peripheral arterial disease (PAD). Different imaging techniques like MRA and CTA provide unique information for precise treatment strategies, especially for chronic limb-threatening ischemia (CLTI).
Area of Science:
- Vascular Medicine
- Medical Imaging
- Diagnostic Technologies
Background:
- Noninvasive imaging is crucial for diagnosing, characterizing, and managing peripheral arterial disease (PAD).
- It provides essential anatomic and physiologic data for personalized therapeutic approaches.
- Various modalities offer complementary information for a comprehensive arterial disease evaluation.
Purpose of the Study:
- To highlight the pivotal role of noninvasive imaging in peripheral arterial disease (PAD) management.
- To outline the distinct contributions of different imaging modalities.
- To emphasize the utility of advanced techniques in chronic limb-threatening ischemia (CLTI).
Main Methods:
- Review of current noninvasive imaging modalities for PAD.
- Discussion of magnetic resonance angiography (MRA), computed tomography angiography (CTA), duplex ultrasonography, and physiologic testing.
- Inclusion of specialized perfusion techniques for chronic limb-threatening ischemia (CLTI).
Main Results:
- Each imaging modality offers unique strengths in evaluating arterial disease.
- Magnetic resonance angiography (MRA) and computed tomography angiography (CTA) provide detailed anatomic information.
- Duplex ultrasonography and physiologic testing offer functional insights, complemented by perfusion techniques for CLTI.
Conclusions:
- Noninvasive imaging is fundamental for the precision therapy of peripheral arterial disease (PAD).
- A multimodal imaging approach ensures comprehensive assessment and effective management.
- Specialized perfusion imaging enhances the diagnostic capabilities for critical limb ischemia (CLTI).
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