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Multifunctionality of TIM-3: from immunological aging to pathological progression

Berta Segura-Collar1,2, Lucía Mondejar-Ruescas3,4, Carmen Jareño-Bonilla3,4

  • 1Instituto de Investigaciones Biomédicas I+12, (Imas12) Hospital 12 de Octubre, Madrid, Spain. bertasegura.imas12@h12o.es.

Npj Aging
|March 14, 2026
PubMed
Summary

No abstract available in PubMed .

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
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