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Related Concept Videos

Proteomics01:33

Proteomics

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A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
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Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
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The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
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Updated: Mar 15, 2026

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Profiling Osteoporosis via Integrated Multi-Omics Technologies.

Adriano Braile1,2,3, Adriano Bani4, Seyedeh Fatemeh Hosseininasab5

  • 1Unit of Orthopaedics and Traumatology, Ospedale del Mare, 80147 Naples, Italy.

Cells
|March 14, 2026
PubMed
Summary
This summary is machine-generated.

Multi-omics approaches reveal complex molecular mechanisms in osteoporosis and osteosarcopenia, aiding biomarker discovery and therapeutic development for bone loss and muscle degeneration.

Keywords:
biomarkersbone–muscle axisepigenomicsmetabolomicsmulti-omicsosteoporosisprecision medicineproteomicstranscriptomics

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Area of Science:

  • Biomedical research
  • Genomics and systems biology

Background:

  • Osteoporosis involves bone loss and muscle degeneration.
  • Multi-omics technologies offer insights into molecular mechanisms, aiding biomarker discovery and therapeutic development.

Purpose of the Study:

  • Synthesize evidence on multi-omics applications in osteoporosis.
  • Focus on molecular insights, methodological diversity, and translational potential.

Main Methods:

  • Scoping review of PubMed, Embase, and Scopus (433 records retrieved).
  • Keywords: osteoporosis, osteosarcopenia, omics.
  • 30 studies included, data extracted on populations, samples, techniques, and integration.

Main Results:

  • Diverse omics techniques (transcriptomics, proteomics, metabolomics, etc.) were used, often integrated computationally.
  • Identified key pathways: osteoclast differentiation, immune regulation, ferroptosis, microbiome-metabolite interactions.
  • Multi-omics enabled identification of molecular subtypes, biomarkers, and therapeutic targets, but limitations in cohort size and validation were noted.

Conclusions:

  • Multi-omics provide a framework for understanding bone and muscle degeneration.
  • Guide precision diagnostics and interventions.
  • Future research needs large, multicenter, longitudinal studies with clinical validation for translation.