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Related Concept Videos

Aging01:26

Aging

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
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Pharmacodynamics in Geriatric Patients: Effects of Age01:27

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Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
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Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
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Drug Dosing: Geriatric Patients01:15

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Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

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As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
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Related Experiment Video

Updated: Mar 15, 2026

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B
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Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B

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Nutritional Strategies and Aging: Current Evidence and Future Directions.

Serena Castelli1,2, Gilda Aiello1, Vincenzo Aiello1,2

  • 1Department for the Promotion of Human Science and Quality of Life, San Raffaele Open University, Rome, Via di Val Cannuta, 247, 00166 Rome, Italy.

Molecules (Basel, Switzerland)
|March 14, 2026
PubMed
Summary

Nutritional strategies can promote healthy aging by targeting molecular factors like oxidative stress and inflammation. This review analyzes dietary interventions to slow aging and improve healthspan.

Keywords:
agingdisease preventionmitochondrial healthnutraceuticalsnutrition-based interventionsoxidative stress

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Last Updated: Mar 15, 2026

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B
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Area of Science:

  • Gerontology and Molecular Biology
  • Nutritional Science

Background:

  • Aging is a degenerative process marked by stem cell depletion and reduced stress response, increasing disease risk.
  • Cellular aging involves mitochondrial dysfunction, DNA repair defects, epigenetic changes, and inflammation.
  • Oxidative stress, caused by reactive oxygen species (ROS), is a key driver of cellular senescence and aging.

Purpose of the Study:

  • To critically review scientific evidence on nutritional approaches for healthy aging.
  • To analyze the molecular mechanisms of dietary interventions in slowing the aging process.

Main Methods:

  • Literature review of scientific evidence on nutritional interventions and aging.
  • Analysis of molecular pathways affected by diet, including inflammation and oxidative stress.

Main Results:

  • Nutritional strategies can modulate key aging pathways.
  • Dietary interventions aim to reduce inflammation and oxidative stress.
  • Preserving mitochondrial function is a key target for anti-aging nutrition.

Conclusions:

  • Nutrition is a critical factor in promoting healthy aging.
  • Dietary interventions can counteract cellular senescence by managing oxidative stress and inflammation.
  • Targeting molecular mechanisms through diet offers a promising strategy to slow aging and extend healthspan.