Association between Psoriasis Area and Severity Index Score and atherosclerotic risk in psoriasis patients using the...

Area of Science:

• Dermatology
• Cardiology
• Public Health

Background:

• Psoriasis is a chronic inflammatory skin condition associated with increased cardiovascular disease (CVD) risk.
• The Hisayama Score is a validated tool for assessing cardiovascular and stroke risk in Japan.

Purpose of the Study:

• To investigate the association between psoriasis severity (PASI) and cardiovascular risk using the Hisayama Score in a Japanese population.
• To evaluate the utility of the Hisayama Score in stratifying cardiovascular risk among psoriasis patients.

Main Methods:

• Retrospective analysis of 71 psoriasis patients (aged 40-79) without pre-existing comorbidities.
• Stratification into low, moderate, and high cardiovascular risk groups based on blood pressure, lipids, and smoking history.
• Application of the Hisayama Score to assess cardiovascular risk in relation to PASI scores.

Main Results:

• Higher PASI scores were significantly associated with increased cardiovascular risk (p=0.003).
• Male patients with PASI scores >10 were more often in moderate or high-risk groups (p=0.049).
• Systolic blood pressure emerged as an independent predictor of cardiovascular risk.

Conclusions:

• Psoriasis severity correlates with elevated cardiovascular risk, underscoring the need for proactive cardiovascular risk management in these patients.
• The Hisayama Score is a useful tool for assessing cardiovascular risk in Japanese psoriasis patients.
• Dermatologists should consider interdisciplinary approaches for managing cardiovascular risk in psoriasis patients.