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Circumscribed Morphea Successfully Treated With Excimer Laser: Analysis of Histopathological Changes
Takuya Takahashi1, Takehiro Takahashi1, Yuichiro Segawa1
1Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.
The Journal of Dermatology
|March 18, 2026
Summary
Excimer laser therapy (ELT) effectively treats localized scleroderma (LSc) by reducing skin hardening and inflammation. This study shows ELT reverses key cellular changes, improving fibrosis in morphea.
Area of Science:
- Dermatology
- Immunology
- Histopathology
Background:
- Localized scleroderma (LSc) is an autoimmune skin disease causing sclerosis.
- Phototherapy, like excimer laser therapy (ELT), is a treatment option for LSc.
- Histopathological changes during ELT for LSc are not well understood.

