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Related Experiment Video

Updated: Mar 19, 2026

Hybrid µCT-FMT imaging and image analysis

Hybrid µCT-FMT imaging and image analysis

Published on: June 4, 2015

Hybrid broken-ray tomography.

Matthew J Faulkner, John C Schotland, Vadim A Markel

Journal of the Optical Society of America. A, Optics, Image Science, and Vision

|March 17, 2026

Summary

This summary is machine-generated.

We developed hybrid broken-ray tomography (HBRT) for 3D imaging of weakly scattering systems. This method uses fluorescent contrast agents and angularly resolved intensity measurements for enhanced imaging capabilities.

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Area of Science:

Medical imaging
Optical tomography
Biophysics

Background:

Accurate 3D imaging of weakly scattering biological systems remains challenging.
Previous methods like broken-ray tomography have limitations in certain applications.

Purpose of the Study:

To introduce a novel hybrid broken-ray tomography (HBRT) method for improved 3D imaging.
To leverage fluorescent contrast agents for enhanced visualization.

Main Methods:

Combines principles of broken-ray tomography and non-reciprocal broken-ray tomography.
Utilizes angularly resolved intensity measurements at incident and fluorescence wavelengths.
Reconstructs optical properties and contrast agent distribution.

Main Results:

Validated HBRT principles using Monte Carlo simulations.
Demonstrated capability to reconstruct attenuation and scattering coefficients.
Enabled reconstruction of fluorescence wavelength attenuation and contrast agent concentration.

Conclusions:

HBRT offers a promising approach for 3D imaging of weakly scattering systems.
The method enhances imaging by incorporating fluorescent contrast agents.
Validated simulation results support the potential of HBRT in biomedical imaging.