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Myeloperoxidase as a Regulator of Cell Signaling under Oxidative/Halogenative Stress

Irina V Gorudko1, Daria V Grigorieva1, Veronika E Reut1

  • 1Belarusian State University, Minsk, 220030, Belarus.

Biochemistry. Biokhimiia
|March 17, 2026
PubMed

Insights

Myeloperoxidase (MPO) regulates cellular signaling during inflammation and oxidative stress. This review highlights MPO's non-catalytic signaling role in cellular processes, distinct from its enzyme activity.

Area of Science:

  • Biochemistry
  • Cell Biology
  • Immunology

Background:

  • Myeloperoxidase (MPO) is an enzyme found in neutrophil azurophilic granules.
  • MPO plays a role in oxidative and halogenative stress during inflammation.
  • Its catalytic activity produces reactive halogen species.

Purpose of the Study:

  • To review the signaling mechanisms of MPO in intracellular and intercellular regulation.
  • To describe MPO's function and reactive halogen species formation.
  • To discuss MPO's non-canonical signaling role.

Main Methods:

  • Literature review focusing on MPO's role in cellular signaling.
  • Analysis of MPO's interaction with NADPH oxidase and reactive oxygen species.
  • Examination of feedback mechanisms involving modified biological molecules.

Main Results:

  • MPO activity and reactive halogen species production depend on NADPH oxidase.
  • Reactive halogen species-modified molecules modulate neutrophil functions like NETosis and exocytosis.
  • MPO exhibits a non-canonical signaling function independent of its catalytic activity.

Conclusions:

  • MPO is a key regulator of cellular signaling pathways during inflammation.
  • Positive feedback loops involving MPO-modified molecules are crucial for neutrophil function.
  • The non-catalytic signaling role of MPO represents a novel area of investigation.
Keywords:
NADPH oxidasecell signalinghalogenative stressmyeloperoxidaseoxidative stressreactive halogen speciesreactive oxygen species

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