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Updated: Mar 19, 2026

Lensfree On-chip Tomographic Microscopy Employing Multi-angle Illumination and Pixel Super-resolution
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Lensless dual-scale coded ptychography microscopy using wavelength-multiplexed illumination.

Yixuan Zhao, Fannuo Xu, Jian Liu

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    Summary
    This summary is machine-generated.

    This study introduces a lensless microscope using wavelength-multiplexed illumination for dual-scale imaging. It balances high resolution and a large field-of-view (FOV) for microscopy applications.

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    Area of Science:

    • Optics and Photonics
    • Microscopy
    • Image Reconstruction

    Background:

    • Lensless microscopy offers advantages in cost and portability.
    • Achieving both high resolution and a large field-of-view (FOV) simultaneously remains a challenge in microscopy.

    Purpose of the Study:

    • To develop a lensless coded ptychographic imaging method for dual-scale image recovery.
    • To achieve a practical balance between resolution and FOV in lensless microscopy.

    Main Methods:

    • Utilized wavelength-multiplexed illumination with plane and spherical waves in a coded ptychographic setup.
    • Developed a dual-constrained ptychographic iterative engine algorithm (DcPIE) for dual-scale data processing.
    • Designed a lensless dual-mode microscope integrating these techniques.

    Main Results:

    • Demonstrated dual-scale image recovery, enabling both large FOV observation and pixel super-resolution.
    • Successfully recovered sample wavefield and mask distribution with high quality.
    • Experimental validation with diverse samples confirmed the method's imaging performance.

    Conclusions:

    • The proposed method provides a practical solution for lensless microscopy.
    • It effectively balances field-of-view and resolution for advanced imaging.
    • This technique advances lensless imaging capabilities for various applications.