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Dynamic Resting-State Network Markers of Disruptive Behavior Problems in Youth.

Heather M Shappell1, Zhiyuan Liu2,3, Mohammadreza Khodaei1,4

  • 1Department of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston-Salem, North Carolina.

Biological Psychiatry Global Open Science
|March 19, 2026
PubMed
Summary
This summary is machine-generated.

Children with disruptive behavior problems show altered brain network connectivity. Dynamic brain network variations, specifically increased time in aberrant cognitive control states, are linked to these behaviors, offering potential biomarkers for youth.

Keywords:
BiomarkerDisruptive behavior disordersDynamic brain networksDynamic connectivityResting-state fMRI

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Area of Science:

  • Neuroscience
  • Developmental Psychology
  • Psychiatry

Background:

  • Childhood disruptive behavior problems are associated with impaired cognitive control networks.
  • The role of dynamic, rather than static, functional brain architecture in these behaviors remains unclear.

Purpose of the Study:

  • To investigate if dynamic functional brain connectivity is distinctly associated with disruptive behavior problems in children.
  • To explore dynamic network properties as potential transdiagnostic markers.

Main Methods:

  • Utilized resting-state functional magnetic resonance imaging (fMRI) data from 877 children (9-10 years old).
  • Employed a hidden semi-Markov model to analyze dynamic connectivity and identify transient brain network states.
  • Assessed occupancy and dwell times in network states, linking them to disruptive behavior severity via linear regression.

Main Results:

  • Increased time spent in network states with aberrant connectivity in cognitive control circuitry (frontoparietal, dorsal attention networks) was linked to disruptive behavior problems.
  • Findings were reliable, with greater severity uniquely associated with increased occupancy time in similar brain states in a held-out sample.

Conclusions:

  • Dynamic resting-state functional connectivity markers may serve as transdiagnostic biomarkers for disruptive behavior problems in youth.
  • These markers could aid in monitoring treatment outcomes, assessing circuit engagement, and informing clinical decisions.