THE IBADAN ACUTE AND CHRONIC HEART FAILURE PROJECT: RATIONALE AND DESIGN.

Area of Science:

• Cardiology
• Public Health
• Genomics

Background:

• Heart failure (HF) in sub-Saharan Africa presents unique challenges, differing from high-income countries.
• Emerging non-communicable forms of HF are increasingly recognized alongside traditional infectious causes.
• Contemporary data indicates a distinct HF demographic, affecting more women and younger individuals.

Purpose of the Study:

• To assess long-term outcomes, risk factors, clinical phenotypes, and genomics of HF in Ibadan, Nigeria.
• To estimate healthcare costs associated with HF and their impact on evidence-based care.
• To understand cultural and social perceptions of HF within Nigeria.

Main Methods:

• Standardized case report forms will collect comprehensive clinical data, including demographics, HF history, symptoms, and risk factors.
• Echocardiography, ECG, and biochemical biomarkers will be utilized for diagnosis and assessment.
• Blood samples will be collected for biomarker analysis and genomic studies.

Main Results:

• Primary outcome: all-cause mortality.
• Secondary outcomes: non-fatal major adverse cardiovascular events, including those leading to or not leading to hospitalization.

Conclusions:

• The study will provide contemporary data on HF etiology, clinical presentation, management, and outcomes in Ibadan.
• Findings are expected to be generalizable to other regions in Nigeria.
• This research will contribute to improved understanding and management of heart failure in the African context.