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Updated: Mar 22, 2026

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Lumbar Spinal Stenosis in Patients with Acromegaly: An MRI-Based Case-Control Study.

Tong Niu1, Xiaopeng Guo2, Yanyan Bian1

  • 1Department of Orthopedics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

World Neurosurgery
|March 20, 2026
PubMed
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Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae·2025

Patients with acromegaly have a significantly higher prevalence of lumbar spinal stenosis (LSS). Early screening for LSS is recommended in acromegaly patients due to increased risk and earlier onset.

Area of Science:

  • Endocrinology
  • Neurosurgery
  • Orthopedics

Background:

  • Acromegaly is associated with various skeletal complications.
  • Lumbar spinal stenosis (LSS) is a common cause of low back pain, particularly in older adults.
  • The relationship between acromegaly and LSS prevalence is not well-established.

Purpose of the Study:

  • To determine the prevalence of LSS in patients with acromegaly.
  • To investigate the risk factors and etiology of LSS in this population.

Main Methods:

  • A case-control study comparing 52 acromegaly patients with 104 age- and sex-matched orthopedic outpatients.
  • Primary outcome: prevalence of LSS. Secondary outcome: dural sac cross-sectional area.
  • Risk factor analysis for LSS within the acromegaly group.
Keywords:
AcromegalyGrowth hormoneLumbar spinal stenosisOsteoarthritisSpine

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Main Results:

  • LSS prevalence was significantly higher in acromegaly patients (67%) versus controls (29%).
  • Acromegaly patients had a 4.8-fold increased odds of LSS and a younger age of onset.
  • Higher nadir growth hormone (GH) levels were independently associated with LSS presence.

Conclusions:

  • Acromegaly patients exhibit a substantially higher prevalence of lumbar spinal stenosis.
  • The findings suggest a need for routine screening for lumbar abnormalities in individuals with acromegaly.