Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Prochirality02:05

Prochirality

5.3K
The concept of prochirality leads to the nomenclature of the individual faces of a molecule and plays a crucial role in the enantioselective reaction. It is a concept where two or more achiral molecules react to produce chiral products. A typical process is the reaction of an achiral ketone to generate a chiral alcohol. Here, the achiral reactant reacts with an achiral reducing agent, sodium borohydride, to generate an equimolar mixture of the chiral enantiomers of the product. For example, an...
5.3K
Chirality02:25

Chirality

32.0K
Chirality is a term that describes the lack of mirror symmetry in an object. In other words, chiral objects cannot be superposed on their mirror images. For example, our feet are chiral, as the mirror image of the left foot, the right foot, cannot be superposed on the left foot.
Chiral objects exhibit a sense of handedness when they interact with another chiral object. For example, our left foot can only fit in the left shoe and not in the right shoe. Achiral objects — objects that have...
32.0K
Chair Conformation of Cyclohexane02:02

Chair Conformation of Cyclohexane

21.2K
The chair conformation is the most stable form of cyclohexane due to the absence of angle and torsional strain. The absence of angle strain is a result of cyclohexane’s bond angle being very close to the ideal tetrahedral bond angle of 109.5° in its chair conformer. Similarly, the torsional strain is also absent owing to the perfectly staggered arrangement of bonds.
The hydrogen atoms linked to carbons are arranged in two different axial and equatorial orientations to achieve this...
21.2K
Stereoisomerism of Cyclic Compounds02:33

Stereoisomerism of Cyclic Compounds

11.8K
In this lesson, we delve into the role of ring conformation and its stability, which determines the spatial arrangement and, consequently, the molecular symmetry and stereoisomerism of cyclic compounds. 1,2-Dimethylcyclohexane is used as a case study to evaluate the possible number of stereoisomers. Here, given the multiple (n = 2) chiral centers, there are 2n = 4 possible configurations that lack a plane of symmetry, as the ring skeleton exists in a non-planar chair conformation. In addition,...
11.8K
Chirality in Nature02:30

Chirality in Nature

17.9K
Chirality is the most intriguing yet essential facet of nature, governing life’s biochemical processes and precision. It can be observed from a snail shell pattern in a macroscopic world to an amino acid, the minutest building block of life. Most of the snails around the world have right-coiled shells because of the intrinsic chirality in their genes. All the amino acids present in the human body exist in an enantiomerically pure state, except for glycine - the sole achiral amino acid.
17.9K
Aromatic Hydrocarbon Anions: Structural Overview01:18

Aromatic Hydrocarbon Anions: Structural Overview

4.3K
Neutral hydrocarbons like cyclopentadiene with an odd number of carbon atoms and one intervening CH2 group in the ring are not aromatic. Cyclopentadiene with 4 π electrons does not satisfy the 4n + 2 π electron rule. Additionally, the intervening CH2 group is sp3 hybridized and lacks a vacant p orbital, thereby interrupting the overlap of p orbitals in a continuous manner and preventing the delocalization of π electrons throughout the ring.
Due to the absence of continuous...
4.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Identification and pathogenicity validation of a novel MLH1 frameshift mutation in Lynch syndrome pedigree.

Gene·2026
Same author

Tumor organoids as a revolutionary platform for advancing cancer nanomedicine.

Molecular cancer·2026
Same author

A Helical Hydrogen-Bonded Aramide Macrocycle with a "Closed" Cavity: Dinuclear Ag(I) Coordination Assembly and Switchable Chirality Sensing.

Inorganic chemistry·2026
Same author

Synthesis and Applications of Sulfur-Containing Macrocycles.

Chemistry (Weinheim an der Bergstrasse, Germany)·2026
Same author

Enhanced performance of a passively mode-locked Tm,Gd:CaF<sub>2</sub> laser versus Tm:CaF<sub>2</sub> around 1.9 μm.

Optics express·2026
Same author

Zwitterionic cross-linked lipoic acid nanocarriers for oral drug delivery.

Nanoscale·2026
Same journal

Machine-Learning-Enabled Rapid Evolution of Photoenzymes for the Asymmetric Synthesis of gem-Difluorophosphonates.

Angewandte Chemie (International ed. in English)·2026
Same journal

Sequential H<sub>2</sub>S-Triggered Redox Relay Nanoprobes for Self-Sustained Chem-Illuminating Cascade Photodynamic Therapy.

Angewandte Chemie (International ed. in English)·2026
Same journal

Quantitative Active Hydrogen Modulation via Mastering Interfacial Water Over Single Rare Earth Atom on Copper for NO<sub>3</sub> <sup>-</sup>-to-NH<sub>3</sub> Electroreduction.

Angewandte Chemie (International ed. in English)·2026
Same journal

Unveiling the Role of Hydroxyls on Catalyst Surface in CO<sub>2</sub> Hydrogenation Reaction.

Angewandte Chemie (International ed. in English)·2026
Same journal

Strain-Release Pentafluorosulfanylation of Carbonyl-Containing Disubstituted Bicyclobutanes: A Fortuitous Path to SF<sub>5</sub>-Containing Oxa[2.1.1]bicyclohexanes.

Angewandte Chemie (International ed. in English)·2026
Same journal

Quantum Spin-1/2 Rings Built From [2]Triangulene Molecular Units.

Angewandte Chemie (International ed. in English)·2026
See all related articles

Related Experiment Video

Updated: Mar 25, 2026

Line Shape Analysis of Dynamic NMR Spectra for Characterizing Coordination Sphere Rearrangements at a Chiral Rhenium Polyhydride Complex
10:52

Line Shape Analysis of Dynamic NMR Spectra for Characterizing Coordination Sphere Rearrangements at a Chiral Rhenium Polyhydride Complex

Published on: July 27, 2022

3.5K

Acetal[6]Arenes: Rigid Chirality-on-Annulus Macrocycles Promoting Charge-Transfer Co-Assembly With Exceptional

Lizhi Fang1, Long Chen1, Yimin Zhu1

  • 1Key Laboratory of Green Chemistry and Technology of the Ministry of Education, College of Chemistry, Sichuan University, Chengdu, China.

Angewandte Chemie (International Ed. in English)
|March 24, 2026
PubMed
Summary
This summary is machine-generated.

New acetal[6]arenes (Ac[6]) macrocycles create charge-transfer complexes with enhanced chiral properties. These rigid structures enable applications in optical sensing and encryption due to their unique guest-capture and chiroptical behaviors.

Keywords:
charge‐transfer complexeschiral macrocyclic areneschirality‐on‐annulustime‐encoded encryption and circularly polarized luminescencevapor‐phase guest capture

More Related Videos

Self-assembling Morphologies Obtained from Helical Polycarbodiimide Copolymers and Their Triazole Derivatives
09:22

Self-assembling Morphologies Obtained from Helical Polycarbodiimide Copolymers and Their Triazole Derivatives

Published on: February 7, 2017

8.3K
Preparation of a Corannulene-functionalized Hexahelicene by CopperI-catalyzed Alkyne-azide Cycloaddition of Nonplanar Polyaromatic Units
09:35

Preparation of a Corannulene-functionalized Hexahelicene by CopperI-catalyzed Alkyne-azide Cycloaddition of Nonplanar Polyaromatic Units

Published on: September 18, 2016

12.2K

Related Experiment Videos

Last Updated: Mar 25, 2026

Line Shape Analysis of Dynamic NMR Spectra for Characterizing Coordination Sphere Rearrangements at a Chiral Rhenium Polyhydride Complex
10:52

Line Shape Analysis of Dynamic NMR Spectra for Characterizing Coordination Sphere Rearrangements at a Chiral Rhenium Polyhydride Complex

Published on: July 27, 2022

3.5K
Self-assembling Morphologies Obtained from Helical Polycarbodiimide Copolymers and Their Triazole Derivatives
09:22

Self-assembling Morphologies Obtained from Helical Polycarbodiimide Copolymers and Their Triazole Derivatives

Published on: February 7, 2017

8.3K
Preparation of a Corannulene-functionalized Hexahelicene by CopperI-catalyzed Alkyne-azide Cycloaddition of Nonplanar Polyaromatic Units
09:35

Preparation of a Corannulene-functionalized Hexahelicene by CopperI-catalyzed Alkyne-azide Cycloaddition of Nonplanar Polyaromatic Units

Published on: September 18, 2016

12.2K

Area of Science:

  • Supramolecular Chemistry
  • Organic Materials Science
  • Chiroptical Spectroscopy

Background:

  • Macrocyclic arenes are known for host-guest chemistry.
  • Carbon-centered chirality in macrocycles is challenging to achieve and control.
  • Developing new supramolecular materials with tunable optoelectronic properties is of great interest.

Purpose of the Study:

  • To introduce a new class of rigid chiral macrocyclic arenes, acetal[6]arenes (Ac[6]).
  • To investigate the charge-transfer (CT) complex formation and chiroptical properties of Ac[6].
  • To explore potential applications of Ac[6]-based materials in sensing and encryption.

Main Methods:

  • Synthesis of acetal[6]arenes (Ac[6]) and their acyclic precursors.
  • Formation and characterization of charge-transfer (CT) complexes using solution and solid-state methods.
  • Single-crystal X-ray diffraction to determine complex structures.
  • Spectroscopic analysis including UV-Vis absorption, fluorescence, and circularly polarized luminescence (CPL).
  • Circular dichroism (CD) spectroscopy.

Main Results:

  • Ac[6] efficiently forms CT complexes with electron-deficient aromatic guests, unlike acyclic precursors.
  • Solid-state complexes exhibit dual emission (fluorescence and TADF) at the CT band.
  • Enantiopure Ac[6] complexes display intense CD and CPL with high dissymmetry factors, indicating efficient chiral transfer.
  • Ac[6] demonstrates robust guest-capture capability via various methods, including gas-phase uptake.
  • Developed applications for optical sensing and time-encoded encryption based on Ac[6] complexes.

Conclusions:

  • Macrocyclization of rigid chirality-on-annulus units is a powerful strategy for creating functional supramolecular CT materials.
  • Ac[6] represents a novel class of macrocycles with significant potential in chiroptical materials and supramolecular chemistry.
  • The unique properties of Ac[6] enable advanced applications in sensing and information security.