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Related Concept Videos

Upstream Processing01:27

Upstream Processing

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Upstream processing represents a critical phase in biomanufacturing, wherein biological systems such as microorganisms, mammalian cells, or insect cells are cultivated to produce therapeutic proteins, vaccines, enzymes, or other biologically derived products. This phase encompasses all steps from the selection and genetic manipulation of the production organism to the cultivation of cells in bioreactors under tightly controlled environmental conditions.Host Selection and Genetic OptimizationThe...
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Bioreactor Controls-III01:22

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Strain improvement is a foundational strategy in industrial microbiology aimed at maximizing microbial productivity, particularly because natural isolates typically yield commercially valuable products in very low concentrations. Although optimizing the culture medium and environmental conditions can improve yields, these adjustments are inherently limited by the organism’s genetic potential. As a result, the focus shifts toward genetic modifications to enhance biosynthetic capacity. The...
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Synthetic Biology02:55

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Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
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Biopesticides offer a sustainable alternative to chemical pesticides, utilizing microbial agents to control agricultural pests. Bacillus thuringiensis (Bt) is a widely employed bacterium known for its potent insecticidal activity. Bt biopesticides are favored for their specificity to insect pests, minimal environmental impact, and natural degradability.Mechanism of Bt Toxin Action Bt produces insecticidal crystal (Cry) proteins during its sporulation phase. These proteins form parasporal...
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Bioplastics01:27

Bioplastics

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Bioplastics derived from microbial processes present a sustainable alternative to conventional petroleum-based plastics. Among these, polyhydroxyalkanoates (PHAs), particularly polyhydroxybutyrates (PHBs), have emerged as prominent candidates due to their biodegradability and biocompatibility. These polymers are synthesized by a variety of bacteria, such as Cupriavidus necator and Pseudomonas putida, which naturally accumulate PHAs as intracellular carbon and energy reserves, especially under...
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Microorganisms play a pivotal role in maintaining ecosystem balance by recycling essential elements such as carbon, nitrogen, and phosphorus, as well as supporting processes like bioremediation, wastewater treatment, and biofuel production.Microbes in Elemental CyclesIn the carbon cycle, microorganisms decompose organic matter, releasing carbon dioxide via aerobic respiration. This carbon dioxide is subsequently used by photosynthetic organisms to synthesize organic compounds, closing the...
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[Biomanufacturing driven by engineered organisms (2026)].

Huawei Zhu1, Yin Li1,2

  • 1Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.

Sheng Wu Gong Cheng Xue Bao = Chinese Journal of Biotechnology
|March 24, 2026
PubMed
Summary
This summary is machine-generated.

Synthetic biology and biomanufacturing are advancing rapidly, driven by artificial intelligence and data-driven approaches. These innovations are expanding biocatalysis, improving cell factories, and enabling sustainable solutions for global challenges.

Keywords:
artificial intelligencebiomanufacturingcell factoryenvironmental remediationenzyme engineeringgreen catalysisinterdisciplinary frontiersneoproteinssynthetic biology

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Area of Science:

  • Synthetic biology and biomanufacturing.

Background:

  • Artificial intelligence (AI) is now central to synthetic biology, shifting research from experience-based to data- and model-driven paradigms.
  • Progress includes advancements in enzyme engineering, protein design, and cell factory optimization.

Purpose of the Study:

  • To review the state of synthetic biology and biomanufacturing in 2025.
  • To highlight the role of AI and emerging technologies in driving innovation.
  • To discuss future directions and applications in environmental remediation and human health.

Main Methods:

  • Review of recent advancements in synthetic biology and biomanufacturing.
  • Analysis of the integration of artificial intelligence across the biomanufacturing pipeline.
  • Exploration of interdisciplinary frontiers like artificial cells and synthetic microbial consortia.

Main Results:

  • AI is a core driver, transforming biomolecular design and fermentation processes.
  • Biocatalysis and cell factory construction show significant progress towards systematic optimization.
  • Environmental bioremediation is moving towards rational design of microbial consortia.
  • Emerging areas like artificial cells are expanding biomanufacturing capabilities.

Conclusions:

  • The future of synthetic biomanufacturing involves deep AI integration, automation, and addressing carbon neutrality and human health.
  • Synthetic biomanufacturing is evolving to create solutions for global resource, environmental, and health challenges.
  • The field is shifting towards creating life for societal good and future sustainability.