High-Throughput Microscale MOF Catalysis via Solid Dispersion Reactor Dosing.

Area of Science:

• Materials Science
• Catalysis
• Chemical Engineering

Background:

• Metal-organic frameworks (MOFs) offer tunable catalytic properties for selective chemical transformations.
• Challenges in MOF catalyst development include poor solubility and difficulties in high-throughput experimentation.

Purpose of the Study:

• To overcome limitations in MOF catalyst optimization using bead-based reactor dosing.
• To develop a rapid, plate-reader-based analysis for MOF formulation optimization.

Main Methods:

• Adaptation of inexpensive bead-based reactor dosing methodologies.
• Development of plate-reader-based analysis for reactor dosing optimization.
• Proof-of-concept study on MOF-catalyzed C-H oxidation reactions.

Main Results:

• Successful adaptation of bead-based dosing for MOF catalyst formulation.
• Demonstrated accurate and precise well-to-well dosing for MOF-bead formulations.
• Identification and optimization of a novel MOF-catalyzed C-H oxidation reaction.

Conclusions:

• Established an accessible workflow for accelerating MOF catalyst development in batch reactions.
• The presented methodology facilitates rapid optimization of MOF catalysts.
• Enables efficient discovery of MOF catalysts for complex chemical transformations.