Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Combined Effects of Drugs: Synergism

Combined Effects of Drugs: Synergism

Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Development of a Protocol for Synthesis of Nitrocinnamonitriles from Nitrotoluenes.

The Journal of organic chemistry·2026

Same author

Development of Two Synthetic Routes to a Benzofuran Intermediate for Fruquintinib.

The Journal of organic chemistry·2025

Same author

Correction to "Synthesis of Secondary <i>N</i>-Methylamines via Reductive Amination of Aldehydes with <i>N</i>-Boc-<i>N</i>-Methylamine Using Me<sub>2</sub>SiHCl".

The Journal of organic chemistry·2025

Same author

Synthesis of Secondary <i>N</i>-Methylamines via Reductive Amination of Aldehydes with <i>N</i>-Boc-<i>N</i>-Methylamine Using Me<sub>2</sub>SiHCl.

The Journal of organic chemistry·2025

Same author

Chemoselective Deprotection of Symmetrically Diprotected Resorcinol <i>N</i>-Methyliminodiacetate (MIDA) Boronates Using the MIDA Boronate Moiety as a Blocking Group: Synthesis of Monoprotected Resorcinol MIDA Boronates.

Organic letters·2024

Same author

Synthesis of 2-(2-nitrophenyl)indoline-3-acetic acid derivatives <i>via</i> base-catalyzed cyclization of <i>N</i>-(2-nitrobenzyl)-2-aminocinnamic acid derivatives.

Organic & biomolecular chemistry·2023

Search research articles

Related Experiment Video

Updated: Mar 27, 2026

Author Spotlight: An Efficient Methodology to Confidently Differentiate and Characterize Fentanyl Analogs

Author Spotlight: An Efficient Methodology to Confidently Differentiate and Characterize Fentanyl Analogs

Published on: November 8, 2024

Total Synthesis of Fexuprazan.

Tae Lyn Kim¹, Jinyeong Jeon¹, Cheol-Hong Cheon¹

¹Department of Chemistry, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul 02841, Republic of Korea.

Organic Letters

|March 26, 2026

Summary

A new, practical synthesis for fexuprazan was developed using Strecker or reductive amination pathways. This efficient route yields gram-scale fexuprazan with simple purification, highlighting its industrial applicability.

Area of Science:

Organic Chemistry
Medicinal Chemistry
Process Chemistry

Background:

Fexuprazan is a potassium-competitive acid blocker.
Developing efficient synthetic routes is crucial for pharmaceutical production.

Purpose of the Study:

To develop a novel and practical synthetic route to fexuprazan.
To achieve gram-scale synthesis with high efficiency and simple purification.

Main Methods:

Two complementary approaches for synthesizing a key N-sulfonyl α-amino ester intermediate.
Utilized Strecker reaction or reductive amination for intermediate synthesis.
Employed Michael addition, intramolecular Wittig reaction, oxidation, decarboxylation, and functional group conversion to obtain fexuprazan.

More Related Videos

Radiosynthesis of 1-2-[18F]Fluoroethyl-L-Tryptophan using a One-pot, Two-step Protocol

Radiosynthesis of 1-2-[18F]Fluoroethyl-L-Tryptophan using a One-pot, Two-step Protocol

Published on: September 21, 2021

Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NFκB Activity and Breast Cancer Stem Cells

Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NFκB Activity and Breast Cancer Stem Cells

Published on: January 18, 2017

Related Experiment Videos

Last Updated: Mar 27, 2026

Author Spotlight: An Efficient Methodology to Confidently Differentiate and Characterize Fentanyl Analogs

Author Spotlight: An Efficient Methodology to Confidently Differentiate and Characterize Fentanyl Analogs

Published on: November 8, 2024

Radiosynthesis of 1-2-[18F]Fluoroethyl-L-Tryptophan using a One-pot, Two-step Protocol

Radiosynthesis of 1-2-[18F]Fluoroethyl-L-Tryptophan using a One-pot, Two-step Protocol

Published on: September 21, 2021

Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NFκB Activity and Breast Cancer Stem Cells

Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NFκB Activity and Breast Cancer Stem Cells

Published on: January 18, 2017

Main Results:

Successfully synthesized fexuprazan via a multi-step sequence.
Demonstrated efficient access to key intermediates.
Achieved gram-scale production with intermediates and final product isolated by simple recrystallization.

Conclusions:

The developed synthetic route is novel, practical, and efficient for fexuprazan production.
The method's simplicity and scalability underscore its potential for industrial application.
Highlights the feasibility of producing fexuprazan on a gram scale with high purity.