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Updated: Mar 27, 2026

Creating Sub-50 Nm Nanofluidic Junctions in PDMS Microfluidic Chip via Self-Assembly Process of Colloidal Particles
Published on: March 13, 2016
SUBTRACTIVE NANOFLUIDICS IN 65-NM CMOS COPPER BEOL ACHIEVE 100-NM WIDTH.
Alexander Di1, Michael Pedowitz1, Jun-Chau Chien1
1University of California, Berkeley, USA.
This study introduces 100-nm nanofluidics on a 65-nm CMOS chip, enabling vertical fluidic channels and demonstrating a new imaging technique for sub-wavelength structures.
Area of Science:
- Semiconductor Manufacturing
- Nanotechnology
- Microfluidics
Background:
- Integrating microfluidic devices with standard semiconductor fabrication processes presents significant challenges.
- Existing methods for creating micro/nanoscale fluidic channels often require specialized equipment or multiple fabrication steps, increasing complexity and cost.
Purpose of the Study:
- To demonstrate the first implementation of 100-nm-wide nanofluidics integrated into a commercial 65-nm CMOS chip.
- To develop a fabrication method compatible with standard CMOS back-end-of-line (BEOL) processing.
- To establish a non-destructive characterization technique for sub-wavelength fluidic structures.
Main Methods:
- Utilized a one-step wet-etch process to remove copper interconnects from the BEOL.
- Employed continuous monitoring of transistor characteristics (IDS-VGS) to ensure device integrity during etching.
- Successfully etched vertical fluidic channels through 360 nm × 360 nm vias.
- Developed a non-destructive laser microscopy technique for imaging channels smaller than the wavelength of visible light.
Main Results:
- Achieved 100-nm-wide nanofluidic channels within a 65-nm CMOS chip.
- Demonstrated the feasibility of vertical fluidics through etched vias.
- Verified transistor integrity was maintained throughout the fabrication process.
- Successfully imaged sub-wavelength fluidic channels using the novel laser microscopy technique.
Conclusions:
- The presented one-step wet-etch method is a viable approach for integrating nanofluidics into standard CMOS technology.
- This integration opens possibilities for novel lab-on-chip devices and advanced sensor applications.
- The developed imaging technique provides essential characterization capabilities for sub-wavelength nanostructures.
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