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Related Concept Videos

Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

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A Single-Cell Atlas of Pan-Cancer Liver Metastasis Reveals Dynamic Cellular Programs Driving Metastatic Progression

Xinyu Tong1,2, Haoyu Chao2,3, Chenlu Zhang2

  • 1Department of Gastroenterology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.

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This study maps the cellular landscape of liver metastasis across cancers using single-cell sequencing. It reveals key cellular programs driving immune evasion and niche formation, offering new therapeutic targets.

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Area of Science:

  • Oncology
  • Immunology
  • Genomics

Background:

  • Liver metastasis poses a significant challenge in cancer care.
  • The cellular and molecular details of liver metastases are not well understood across various cancer types.

Purpose of the Study:

  • To create a comprehensive single-cell transcriptomic atlas of liver metastases.
  • To identify cellular programs and understand their role in metastatic progression and immune modulation.

Main Methods:

  • Analysis of 100 single-cell RNA sequencing samples, profiling over 460,000 cells.
  • Identification of 121 distinct cellular subtypes and 4 representative cellular programs (CPs).

Main Results:

  • Defined 4 CPs associated with liver metastasis, illustrating shifts from immune activity to immunosuppression.
  • Revealed dynamic changes in immune infiltration, stromal remodeling, and tumor adaptations.
  • Elucidated mechanisms of immune evasion and metastatic niche formation.

Conclusions:

  • The study provides a high-resolution framework for liver metastasis heterogeneity.
  • Cellular programs offer potential for stratifying patients and informing targeted therapies for the metastatic tumor microenvironment.