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Updated: Mar 28, 2026
Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring
Published on: December 14, 2020
Treatment Adherence in Laryngopharyngeal Reflux: A Prospective, Blinded Study of Influencing Factors and Their Impact
Melih Alpay1, Nesibe Gül Yüksel Aslier1, Çağlar Çelik1
1Bursa High Specialty Training and Research Hospital, Department of Otolaryngology, University of Health Sciences, Bursa, Turkey.
Objective:
Laryngopharyngeal reflux (LPR) patients are commonly prescribed proton pump inhibitors (PPIs) alongside diet/lifestyle modifications, but poor medication adherence undermines treatment effectiveness. The aim of this study is to evaluate adherence to medical treatment in LPR patients and to determine factors affecting medication compliance.
Materials And Methods:
Patients with clinically diagnosed LPR and a Turkish Reflux Symptom Index (RSI) score ≥13 received rabeprazole 20 mg twice daily. Those attending follow-up visits at months 1, 2, and 3 completed the Turkish-validated eight-item Morisky Medication Adherence Scale (MMAS-8) and the RSI questionnaire.
Results:
This study included a total of 40 cases (24 women, 16 men) with mean age of 48.12 years and RSI score above 13. In the first month evaluation, married participants had better medication adherence than single participants (P = 0.016), unemployed participants had better adherence than employed participants (P = 0.023), and participants not using multiple medications had better adherence than those using multiple medications (P = 0.034). Among employed individuals, shift workers showed lower treatment adherence (P = 0.029).). Overall, no significant correlations were found between RSI and MMAS-8. RSI scores decreased significantly at the 3rd month compared to baseline, and in time-dependent changes between baseline, 1st month, 2nd month, and the 3rd month follow-ups (P < 0.001). At the 3rd month, MMAS-8 scores increased significantly compared to the first month (P = 0.005) and time-dependently (P < 0.001) as well, indicating symptom improvement accompanied by enhanced medication adherence.
Conclusion:
In this study, married participants, non-working participants, non-shift workers, and participants without multiple medications complied better to medication use. Low initial adherence followed by time-dependent improvement suggests that early counseling is critical for long-term patient compliance.
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