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Tracking the Metabolites of Health and Disease Using Artificial Intelligence
Ahmed Fadiel1, Kenneth D Eichenbaum2,3, Aya Hassouneh4
1Computational Oncology Unit, University of Chicago Medicine Comprehensive Cancer Center, 900 E 57th St, KCBD Bldg., Chicago, IL 60637, USA.
Diseases (Basel, Switzerland)
|March 27, 2026
Summary
Artificial intelligence (AI) analyzes metabolite profiles for health insights. AI accelerates biomarker discovery and optimizes interventions for precision medicine, advancing diagnostics and drug discovery.
Area of Science:
- Biochemistry
- Bioinformatics
- Computational Biology
Background:
- Metabolomic signatures offer insights into health, aging, and disease.
- Metabolites reflect lifestyle and therapeutic impacts on organ function and cancer.
- High-throughput metabolomic data analysis is crucial for understanding biological systems.
Purpose of the Study:
- To review emerging AI toolkits for analyzing metabolomic data.
- To emphasize the integration of AI with other omics (genomics, proteomics, etc.).
- To demonstrate AI's potential in diagnostics, drug discovery, and precision medicine.
Main Methods:
- Review of current AI methodologies for metabolomic data analysis.
- Highlighting integration strategies with multi-omics data.
- Focus on AI applications for metabolic pathway mapping and biomarker discovery.
Main Results:
- AI enables sophisticated analysis of complex metabolite profiles.
- Integration with multi-omics enhances biological interpretation.
- AI accelerates the identification of novel biomarkers and therapeutic targets.
Conclusions:
- AI is a powerful tool for advancing metabolomics research.
- AI facilitates personalized interventions and precision medicine.
- AI significantly impacts diagnostics and accelerates drug discovery pipelines.
Keywords:
artificial intelligencebioinformaticscancerdrug development pipelinesmetabolomicsmulti-omics
